Increased Risk Of Bone Fractures With Proton Pump Inhibitors: An Update.

Proton Pump Inhibitors (PPIs) are a group of drugs whose main action is to produce a pronounced and long-lasting reduction of gastric acid secretion, which makes them useful in a series of pathological conditions such as heartburn, peptic and duodenal ulcers, gastroesophageal reflux disease (GERD) and Zollinger-Ellison syndrome, among others. 

Although PPIs have proven to have a very favorable safety profile, the increasing number of patients who take them for chronic conditions, such as GERD, has focused the attention of the authorities on their long-term potential adverse effects. 

https://www.c-therapeutics.com/news-increased-risk-of-fractures/